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Changes in the ratio of urinary α1‐microglobulin to ulinastatin levels in patients with Alzheimer‐type dementia and vascular dementia
Author(s) -
INAGAKI TAKUJI,
SHIKIMI TADAHIRO,
ISHINO HIROSHI,
OKUNISHI HIDEKI,
TAKAORI SHUJI
Publication year - 1995
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1995.tb01903.x
Subject(s) - ulinastatin , dementia , vascular dementia , medicine , beta 2 microglobulin , urinary system , alzheimer's disease , gastroenterology , correlation , endocrinology , central nervous system disease , psychology , disease , geometry , mathematics
Relationships between urinary levels of α1‐microglobulin (α1M) and ulinastatin (UT) in patients with dementia were investigated. There were no significant differences in α1M and UT levels and α1M: UT ratios among three groups: age‐matched control subjects, patients with either Alzheimer‐type senile dementia (ATD) or vascular dementia (VD). Although a positive correlation was established between α1M and UT levels in these groups, the regression of the demented patients differed significantly from that of controls ( P <0.05). A tendency towards a negative correlation between α1M: UT ratios and the levels of severity or duration of the disease was displayed in the ATD group, whereas a tendency toward a positive correlation between α1M: UT ratios and the levels of severity was observed in the VD group. These results suggest that changes in the relationships between urinary levels of α1M and UT may provide a useful biochemical index for diagnoses of ATD and VD.