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Dopamine D 1 and D 2 Receptor Antagonists Suppress Acute Stimulant Action of Cocaine, but Enhance Cocaine Sensitization
Author(s) -
Kuribara Hisashi
Publication year - 1994
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1994.tb03093.x
Subject(s) - stimulant , sch 23390 , sensitization , pharmacology , dopamine , dopamine receptor , chemistry , medicine , anesthesia , immunology
The ambulation increase caused by the repeated dosing of cocaine (10 mg/kg s. c.) was dose‐dependently reduced by the simultaneous administration of the selective dopamine D 1 and D 2 receptor antagonists, SCH 23390 (0.01, 0.03 and 0.1 mg/kg s. c.) and YM‐09151‐2 (nemonapride) (0.01, 0.03 and 0.1 mg/kg s. c.), respectively. However, the mice given cocaine with SCH 23390 (0.03 mg/kg) and cocaine with YM‐09151‐2 (0.03 and 0.1 mg/kg) 5 times at 3 to 4‐day intervals showed significantly higher sensitivity than the mice given cocaine alone to the challenge cocaine. The present results suggest that, although the blockade of either dopamine D 1 or D 2 receptor is effective for a reduction in the stimulant action of cocaine, such treatment enhances the induction of cocaine sensitization.