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Single Photon Emission Computed Tomography (SPECT) Findings Using N‐Isopropyl‐p‐[ 123 I]iodoamphetamine ( 123 I‐IMP) in Schizophrenia and Atypical Psychosis
Author(s) -
Suga Hidemichi,
Hayashi Takuji,
Mitsugi Ohara
Publication year - 1994
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1994.tb03085.x
Subject(s) - psychosis , single photon emission computed tomography , schizophrenia (object oriented programming) , psychology , positron emission tomography , isopropyl , nuclear medicine , etiology , psychiatry , medicine , chemistry , organic chemistry
As a basis for possible classification of schizophrenic psychoses into schizophrenia and atypical psychosis, we studied the brain functional differences among 16 schizophrenic patients, 16 atypical psychosis patients and 16 healthy volunteers by single photon emission computed tomography (SPECT) using N‐isopropyl‐p‐[ 123 I]iodoamphetamine. As a result, schizophrenics showed hypofrontality. On the other hand, atypical psychotics had no such hypofrontality but showed a reduced uptake rate in the right thalamic region. No influence of sex, duration of illness and medication was confirmed by the findings. The results suggest that schizophrenics might have some lesions in the frontal regions, whereas atypical psychotics might have no such lesions, but dysfunction in the right thalamic region. Consequently, the SPECT findings at least indicate possibly different etiologies for schizophrenia and atypical psychosis.