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Incidence of “Typical Cases” and “Incomplete Cases” of Neuroleptic Malignant Syndrome and Their Epidemiological Study
Author(s) -
Tsutsumi Yasuhiko,
Yamamoto Kenji,
Hata Shunji,
Sakai Masao,
Shirakura Katsuyuki
Publication year - 1994
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1994.tb03080.x
Subject(s) - incidence (geometry) , epidemiology , neuroleptic malignant syndrome , medicine , pediatrics , surgery , physics , optics
In order to find the incidence of “typical cases” and “incomplete cases” of neuroleptic malignant syndrome (NMS), we reviewed 30 cases, which were treated as NMS among 888 inpatients, in light of Adityanjee's and Pope's diagnostic criteria. Further to consider the differences between the cases which could be diagnosed with NMS or not, we studied the epidemiological matters between the cases which met Pope's diagnostic criteria (Group P) and not (Group N). As a result, the proportion of the cases which met Adityanjee's diagnostic criteria was 0.23% (n=2) and Pope's was 2.36% (n=21). An interesting difference between Group P and Group N was the dose of neuroleptics. The dose in terms of an equivalent dose of chlorpromazine was high in Group N at 801 mg against 580 mg in Group P.