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Low Levels of Serum Apolipoprotein AI and AII in Senile Dementia
Author(s) -
Kuriyama Masaru,
Takahashi Kanehisa,
Yamano Takashi,
Hokezu Yoichi,
Togo Seiji,
Osame Mitsuhiro,
Igakura Takeshi
Publication year - 1994
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1994.tb03019.x
Subject(s) - apolipoprotein b , dementia , medicine , apolipoprotein e , vascular dementia , pathological , endocrinology , lipoprotein , cholesterol , senile dementia , high density lipoprotein , psychology , disease
We studied the serum lipoprotein and apolipoprotein profiles in 44 patients with sporadic late‐onset Alzheimer's dementia and 43 patients with vascular dementia. The levels of high‐density lipoprotein (HDL) cholesterol were lower in both patient groups than in a control group. Apolipoprotein A I and A II levels have decreased in both the patient groups, especially in the vascular dementia group. The HDL‐cholesterol levels correlated positively with the level of apolipoprotein A I, but not with the level of apolipoprotein A II. The ratios of apolipoprotein A I/A II have increased in both the patient groups. The apolipoprotein A II levels have disproportionally decreased in the patient groups. The serum apolipoprotein A II may involve the pathological process in the patients with senile dementia.