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A Theoretical and Neurophysiological Consideration on the Pathogenesis of Positive Symptoms of Schizophrenia: Implications of Dopaminergic Function in the Emotional Circuit
Author(s) -
Maeda Hisao
Publication year - 1994
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1994.tb03003.x
Subject(s) - neuroscience , glutamatergic , dopaminergic , neurophysiology , schizophrenia (object oriented programming) , neuropharmacology , dopamine , mechanism (biology) , gating , prefrontal cortex , psychology , psychosis , sensory gating , limbic system , medicine , psychiatry , central nervous system , glutamate receptor , philosophy , receptor , cognition , epistemology
The implications of the emotional circuit and the gating mechanism by dopamine (DA) proposed by Maeda 72,73 in the pathogenesis of positive symptoms of schizophrenia were reconsidered based upon recent advances and findings in the fields of neurophysiology and neuropharmacology and in biological studies of schizophrenia. The gating mechanism by DA was partly supported by new evidence that glutamatergic or GABAergic neurotransmission, which mediates the hippocampo‐lateral septal or the piriform cortico‐amygdaloid neuronal connections, is likely to be modulated by DA. The compensation‐facilitating or gating functions of DA was considered again to play an important role in producing positive symptoms in schizophrenics, who have been suggested to have morphological abnormalities in the limbic system or in the prefrontal cortex prior to the appearance of positive symptoms.