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Morphological Investigation of Neurofibrillary Tangles in Alzheimer's Disease
Author(s) -
Miyakawa Taihei,
Katsuragi Shoichi,
Yamashita Kensho,
Ohuchi Kiyoshi
Publication year - 1994
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1994.tb02995.x
Subject(s) - tubule , senile plaques , neuroscience , fibril , alzheimer's disease , disease , chemistry , pathology , anatomy , biology , medicine , biochemistry , endocrinology , kidney
Abstract: There are two types of neurofibrillary tangles, namely, a twisted tubule and a straight or uniform tubule in the same cell in the brain with Alzheimer's disease. However, in some parts of the same fibril, both the twisted and straight tubules clearly could be seen as a continuation of each other. This finding suggests that both of the tubules have a deep relation to each other, especially at the molecular level. This might also suggest the possibility of both tubules which mutually transform into each other.