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Correlation between Event‐Related Potentials and MR Measurements in Chronic Alcoholic Patients
Author(s) -
Kaseda Yumiko,
Miyazato Yoshikazu,
Ogura Chikara,
Nakamoto Haruo,
Uema Takeshi,
Yamamoto Kazuyoshi,
Ohta Ikuya
Publication year - 1994
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1994.tb02992.x
Subject(s) - n100 , event related potential , abnormality , audiology , psychology , correlation , cardiology , chronic alcoholic , medicine , neuroscience , electroencephalography , psychiatry , mathematics , geometry
Event‐related potentials were recorded in 25 abstinent alcoholics, and 25 gender‐and age‐matched controls during a two‐tone discrimination (odd ball) task. All the subjects were free from medication and dextral. MR images were examined in the alcoholics. The amplitudes of N100, N200 and P300 in the alcoholics were reduced compared with those of the controls. In order to identify morphological changes responsible for ERP abnormalities, linear regression analyses were performed between ERP measures and MRI parameters. The amplitude of N100 was inversely correlated with ventricular size. The amplitudes of P300 were inversely correlated with both ventricular size and width of cortical sulci. It was suggested that the N100 abnormality was related to subcortical structure, and P300 alteration was related to both subcortical and cortical structures in the alcoholics.