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Functional Brain Imaging of a Catatonic Type of Schizophrenia: PET and SPECT Studies
Author(s) -
Satoh Keiji,
Narita Minoru,
Someya Toshiyuki,
Fukuyama Hidenao,
Yonekura Yoshiharu
Publication year - 1993
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1993.tb01836.x
Subject(s) - positron emission tomography , cerebral blood flow , parietal lobe , frontal lobe , single photon emission computed tomography , temporal lobe , neuroscience , emission computed tomography , psychology , spect imaging , neuroimaging , nuclear medicine , medicine , epilepsy
A brain imaging study was conducted in the case of a catatonic type of schizophrenia (DSM‐IIIR) by applying (i) positron emission tomography (PET) and (ii) single photon emission computed tomography (SPECT). A PET study using [ 18 ]‐2‐fluoro‐2‐deoxy‐D‐glucose revealed a lower glucose utilization in the dorsal frontal and parietal lobes of both cerebral hemispheres. Correlative SPECT studies using [ 123 I]‐iodoamphetamine showed a diminished regional cerebral blood flow in similar regions of the cerebral hemisphere. A three‐dimensional volume rendering method of the SPECT images (TITAN) identified the dorsal region of the fronto‐parietal lobe as the most severely affected region. These patterns of deficits implicated the role of the dorsal frontal and parietal lobes in the pathogenesis of catatonic syndromes.