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Paradoxical GABAergic Facilitation on Seizure Development Observed from Bicuculline‐Induced Effects on Visual Cortical Kindling at Short Interstimulus Intervals in Chronically Prepared Rabbits
Author(s) -
Kurokawa Kenzo,
Jibiki Itsuki,
Kubota Takashi,
Fukushima Toshinobu,
Fujimoto Kimio,
Wakita Shigeki,
Yamaguchi Nariyoshi
Publication year - 1993
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1993.tb01816.x
Subject(s) - bicuculline , kindling , gabaergic , hippocampal formation , gabaa receptor , neuroscience , gaba receptor antagonist , kindling model , hippocampus , facilitation , inhibitory postsynaptic potential , chemistry , psychology , endocrinology , epilepsy , medicine , receptor
To investigate the influence of GABAergic function on seizure development, the effects of bicuculline, a GABAa receptor antagonist, on visual cortical and hippocampal kindling were examined in chronically prepared rabbits. Kindling‐inducing stimulations were repeated at 5‐min intervals. The changes in afterdischarge (AD) durations were compared before and 30 min after a low (2 mg/kg) and high dose (5 mg/kg) i.p. injection of bicuculline solution. In the visual cortical kindling group, the AD durations were markedly shortened after the low dose bicuculline injection, while bicuculline produced a prolongation of the AD durations in the visual cortical with the high dose injection and hippocampal kindling groups. The low dose bicuculline‐induced inhibition of visual cortical kindling suggests facilitative GABAergic action on seizure development, while the drug‐induced enhancement in the other groups reflects the well‐known inhibitory GABAergic action.