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Classification of Senile Plaques by Three‐Dimensional Analysis
Author(s) -
Kimura Takemi,
Hisano Toshiyuki,
Yoshida Hiroyuki,
Ueda Keishi,
Miyakawa Taihei
Publication year - 1993
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1993.tb01814.x
Subject(s) - medicine , psychology , neuroscience
We evaluated the number of each senile plaque subtype in Alzheimer's brain by the usual two‐dimensional analysis using a single, methenamine silver stained section and three‐dimensional analysis using serial section reconstruction. The number of classic plaques was underestimated due to a lack of precision in the usual evaluating procedures (two‐dimensional analysis), while that of stellate deposits was overestimated. From these results, it was suggested that the three‐dimensional analysis by gapless serial sections was indispensable to examine and subclassify senile plaques.