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An Autopsy Case of Coexisting Portal Systemic Encephalopathy and Senile Dementia of the Alzheimer Type
Author(s) -
Asada Takashi,
Kobayashi Makio,
Hirano Masami,
Atobe Masaru
Publication year - 1993
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1993.tb01813.x
Subject(s) - pathology , autopsy , cerebral amyloid angiopathy , medicine , dementia , grocott's methenamine silver stain , encephalopathy , alzheimer's disease , amyloid (mycology) , pathological , senile plaques , angiopathy , staining , disease , endocrinology , diabetes mellitus
An autopsy case of portal systemic encephalopathy and senile dementia of the Alzheimer type coexisting in a 77‐year‐old man is described. The patient had suffered recurrent episodes of delirium after a subtotal gastrectomy for gastric carcinoma. He died of DIC 45 months after the gastrectomy. A pathological examination revealed a vascular plexus around the liver which might have served as collateral circulation. Neuropathologically, spongy necrosis and Alzheimer type II changes of astrocytes were found in the basal ganglia and fronto‐occipital cortices. In the same anatomical regions, only immunohistological staining using antibody against amyloid β‐protein and the periodic‐acid methenamine silver method revealed abundant neuriticplaques, cerebral amyloid angiopathy and diffuse plaques. We discussed the clinicopathological findings in this case.