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Concentration of Neural Thread Protein in Cerebrospinal Fluid from Progressive Supranuclear Palsy and Parkinson's Disease
Author(s) -
Yamada Tatsuo,
Chong Jonathan K.,
Asahina Masato,
Koguchi Yorio,
Hirayama Keizo
Publication year - 1993
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1993.tb01809.x
Subject(s) - progressive supranuclear palsy , cerebrospinal fluid , pathology , pathological , medicine , degenerative disease , parkinson's disease , alzheimer's disease , dementia , disease , neuroscience , psychology
We measured the concentration of neural thread protein (NTP) in cerebrospinal fluid (CSF) by an automatized microparticle enzyme immunoassay from 11 progressive supranuclear palsy (PSP) patients and 11 Parkinson's disease (PD) patients and 7 patients with cervical spondylosis as controls. The mean levels did not differ significantly among the groups. In the PSP group, however, the levels correlated significantly with the severity of motor symptoms, signs and functional disability but not with dementia, while the opposite was true in the PD group. The elevated levels in PSP cases may reflect an increase with progression of the disease in such pathological structures as neurofibrillary tangles or neuropil threads, while in PD such levels may indicate associated Alzheimer‐type pathology.