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Myoclonus and Seizures in a Patient with Parkinsonism: Induction by Levodopa and Its Confirmation on SEPs
Author(s) -
Yoshida Kazuto,
Moriwaka Fumio,
Matsuura Toru,
Hamada Takeshi,
Tashiro Kunio
Publication year - 1993
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1993.tb01808.x
Subject(s) - myoclonus , parkinsonism , somatosensory evoked potential , anesthesia , discontinuation , levodopa , medicine , psychology , electroencephalography , carbidopa , neuroscience , surgery , parkinson's disease , disease
A 68‐year‐old woman with parkinsonism showed cortical myoclonus and seizures under antiparkinsonian medication. Myoclonus was induced and enhanced by L‐dopa, developing into generalized seizures. EEG was abnormal and somatosensory‐evoked potentials (SEPs) showed giant SEPs, transcortical reflex (C reflex) and jerk locked potentials. Myoclonus and seizures disappeared after discontinuation of L‐dopa and the introduction of valproate sodium (VPA). We described the occurrence of L‐dopa‐induced myoclonus and seizures in a case of parkinsonism with its SEPs findings.