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The Biological Background of Refractory Schizophrenia: A Study on Clinical States, Serum Drug Concentration, Cognitive Function and Brain CT Findings
Author(s) -
Hori Akira,
Nagayama Motowo,
Shimada Hitoshi
Publication year - 1993
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1993.tb01793.x
Subject(s) - schizophrenia (object oriented programming) , delusion , rating scale , affect (linguistics) , refractory (planetary science) , psychology , cognition , psychiatry , medicine , pediatrics , developmental psychology , physics , communication , astrobiology
Inpatients who had been in the hospital for more than three years (refractory group, n=53) were compared with outpatients who had not been admitted to the hospital in the last three years (remission group, n=42). There were differences between the two groups in “blunted affect‐thought disturbance” symptoms, “hallucination‐delusion” symptoms, the score of behavior rating scale (BRS), the dosage and serum concentration of antipsychotics, the score of Hasegawa's Dementia Scale (HDS) and brain CT findings. “Blunted affect‐thought disturbance” symptoms were strongly related to the BRS score, the dosage of antipsychotics and the HDS score. Sylvian fissures enlargement was related to “blunted affect‐thought disturbance” symptoms. Sylvian fissures enlargement was thought to be a biological background of refractory schizophrenia.