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The Role of Cholinergic Neurons in Stress‐Induced Increase of Interictal Discharges in Hippocampal‐Kindled Rats
Author(s) -
Komatsu Kazuhisa
Publication year - 1992
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1992.tb02866.x
Subject(s) - hippocampal formation , cholinergic , neuroscience , ictal , hippocampus , chemistry , psychology , epilepsy
This study aims to clarify the role of cholinergic neurons in the occurrence of epileptic seizures when emotional stress is loaded. The effects of streaa and drugs on hippocampal interictal discharges were compared among groups of fully kindled male Wistar rats intraperitoneally gtven atropine, physostigmine and saline with and without immobilization, or pituitary‐adrenocortical hormones without immobilization. Hippocampal interictal discharges increased during immobilization, because hippocampal cholinergic neurons were activated by emotional stress. Pituitary‐adrenocortical hormones had no effects on the discharges.