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Comparison of Thyroid Function between Responders and Nonresponders to Thyroid Hormone Supplementation in Depression
Author(s) -
Nakamura Toyonori,
Nomura Junichi
Publication year - 1992
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1992.tb02859.x
Subject(s) - triiodothyronine , medicine , endocrinology , thyroid , hormone , thyroid function , depression (economics) , thyroid stimulating hormone , antidepressant , hypothalamic–pituitary–thyroid axis , hippocampus , economics , macroeconomics
The serum levels of thyroxine (T 4 ), 3,5,3′‐triiodothyronine (T 3 ) and 3,3′,5′‐triiodothyronine (reverse T 3 , r T 3 ) were examined from 8 depressed patients who did not maximally benefit from conventional antidepressant therapy. Four of the 8 depressed patients showed significant clinical improvement after thyroid hormone was added to their ongoing antidepressant drugs. The T 4 and r T 3 levels prior to thyroid hormone supplementation were significantly lower in responders than in nonresponders, although within the normal range. Furthermore, all of the patients who had both their r T 3 levels less than 200 pg/ml and T 4 levels less than 7 μ/dl responded to the thyroid hormone treatment. These data suggest that the lower T 4 and r T 3 levels can predict the treatment response to the thyroid hormone supplementation in depressed patients.