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Voluntary Intake of Alcohol Is Attenuated by Ipsapirone in Mice and Role of 5–HT 1A Receptor
Author(s) -
Chen ChiaoChicy,
Fujiwara Yutaka,
Akiyama Kazufumi,
Ujike Hiroshi,
Moriya Fumio,
Otsuki Saburo
Publication year - 1992
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1992.tb00834.x
Subject(s) - ipsapirone , chemistry , agonist , 5 ht1a receptor , 5 ht receptor , receptor , endocrinology , serotonin , medicine , tryptamine , alcohol , neurotransmitter , ethanol , pharmacology , psychology , biochemistry
Abstract: Emerging evidences have suggested that the brain serotonin (5‐hydroxy‐tryptamine, 5‐HT) neurotransmitter system is involved in the compulsive alcohol‐seeking behaviors in humans and animal models. The aim of this study is to examine the effect of ipsapirone, which is a specific 5‐HT 1A , agonist with a pyrimidinylpiperazine structure, on alcohol consumption in mice (C57BL/6J) by a voluntary alcohol intake paradigm. When the consumed 8, kohol was expressed as g/kg B.W., the total 12‐day amount was significmtly lower in the ipsapirone‐treated mice than in the saline‐treated mice. However, 5‐HT 1A receptor binding sites labeled with [ 3 H]8‐OH‐DPAT in hippocampal membranes did not differ significantly in either the total number of binding sites (Bmax) or dissociation constant (Kd) between the two groups. The possible mechanism regarding the role of ipsapirone that attenuated the alcohol consumption, and its relationship to the subtyping 5‐HT receptors are further discussed.