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Usefulness of Antiparkinsonian Drugs during Neuroleptic Treatment and the Effect of Clonazepam on Akathisia and Parkinsonism Occurred after Antiparkinsonian Drug Withdrawal: A Double‐Blind Study
Author(s) -
Horiguchi Jun,
Nishimatsu Ohichi
Publication year - 1992
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1992.tb00549.x
Subject(s) - akathisia , clonazepam , parkinsonism , medicine , drug withdrawal , anesthesia , psychology , drug , antipsychotic , pharmacology , schizophrenia (object oriented programming) , psychiatry , disease
Antiparkinsonian drugs used for 117 : chronic schizophrenic patients receiving long‐term neuroleptic treatment were withdrawn. Seventy‐eight (66.7%) of the 117 : patients were without akathisia and/or parkinsonism at least for 6 : weeks after the antiparkinsodan drug withdrawal. A double‐blind study of clonazepam was carried out for 22 : patients and clonazepam was effective on 8 : patients (100%) with akathisia and on 3 : patients (75%) with parkinsonism. The authors conclude that these data support the need for discontinuous use of antiparkinsonian medication during the long‐term neuroleptic therapy of chronic schzophrenic patients and the effectiveness of clonazepam in managing antiparkinsonian drug withdrawal‐induced akathisia and parkinsonism.