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Distinguishing Acute and Tardive Akathisia by Monitoring Microvibration: A Pilot Study
Author(s) -
Nishikawa Tadashi,
Kuwahara Hiroo,
Tsuda Akira,
Tanaka Masatoshi,
Koga Itsuyuki,
Uchida Yasunori
Publication year - 1992
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1992.tb00541.x
Subject(s) - akathisia , tardive dyskinesia , dystonia , anesthesia , psychology , dyskinesia , extrapyramidal symptoms , medicine , psychiatry , antipsychotic , schizophrenia (object oriented programming) , parkinson's disease , disease
One acute and one tardive akathisia patients, respectively, and 10 : neuroleptic‐treated schizophrenic patients were injected with biperiden 5 : mg or saline and the response to anticholinergics was monitored by microvibration (MV) as an indicator of muscle tonus. These data were subjected to the Fast Fourier Transform and an averaged power spectrum was computed. The biperiden injection markedly reduced the power spectral values of MV in acute akathisia. In contrast with acute akathisia, the biperiden injection sigdlcantly increased the power spectral values of MV in tardive akathisia. The subjective feelings of akathisia patients were parallel to the power spectral values of MV. Control patients were not aflected by such treatment. The present findings show that the subjective symptoms of akathisia can be well defined by the objective, differential response to anticholinergics in a manner similar to the visible extrapyramidal symptoms (dystonia, dyskinesia) induced by neuroleptics.