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An Important Role of Non‐NMDA Receptors in the Expression of Kindled Amygdaloid Seizure in Rats
Author(s) -
Saitoh Hiroki,
Osonoe Kouichi,
Osonoe Minako,
Mori Norio,
Kumashiro Hisashi
Publication year - 1991
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1991.tb02497.x
Subject(s) - kainate receptor , nmda receptor , kindling , receptor , kainic acid , stimulation , neuroscience , amygdala , seizure threshold , 2 amino 5 phosphonovalerate , epilepsy , chemistry , glutamate receptor , medicine , endocrinology , psychology , biology , anticonvulsant , ampa receptor , biochemistry , excitatory amino acid antagonists
γ‐D‐glutamylaminomethylsulphonic acid (GAMS), a preferential antagonist of non‐NMDA receptors (kainate and quisqualate receptors), was injected into the kindled amygdala (AM) of rats. When the kindled AM was stimulated at the previously established generalized seizure triggering threshold (GST) one hour after the GAMS (1 or 2 mu;mol) injection, afterdischarge (AD) generation was completely suppressed. However, a re‐stimulation at the intensity of 40–200 μA above the GST generated AD associated with Stage 1 or 5 seizure. Our result suggests an important role played by non‐NMDA receptors in the expression and generalization of AM‐onset seizures.