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Monotherapy for Childhood Epilepsies with Zonisamide
Author(s) -
Kumagai Noboru,
Seki Tohru,
Yamawaki Hidenori,
Suzuki Nobuyuki,
Kimiya Satoshi,
Yamada Tetsuya,
Hara Mitsuhiro,
Hashimoto Rintaroh,
Takuma Yuuichi,
Hirai Katsuaki
Publication year - 1991
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1991.tb02487.x
Subject(s) - zonisamide , pediatrics , partial seizures , medicine , partial epilepsy , epilepsy , side effect (computer science) , anesthesia , drug , psychiatry , computer science , topiramate , programming language
Zonisamide was tried on 44 children, 18 girls and 26 boys, from 8 months to 15 years of age at the start of the trial. In 6 children the drug has been stopped because of side effects. The drug was introduced at a dose of 2–4 mg/kg/day and increased to 12 mg/kg/day unless a satisfactory response occurred at a lower dose. A 100% control of seizures was achieved in 5 of 5 cases of idiopathic generalized epilepsies, in 7 of 8 cases of symptomatic generalized epilepsies, in one of one case of idiopathic partial epilepsies, and in 17 of 24 cases of symptomatic partial epiSepsies. The main side effect was drowsiness, especially during the introduction.