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Long‐Lasting Enhancement of the Membrane‐Associated Protein Kinase C Activity in the Hippocampal Kindled Rat
Author(s) -
Daigen Akihiro,
Akiyama Kazufumi,
Itoh Takashi,
Kohira Ichiro,
Sora Ichiro,
Morimoto Kiyoshi,
Otsuki Saburo
Publication year - 1991
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1991.tb02475.x
Subject(s) - kindling , protein kinase c , hippocampal formation , hippocampus , chemistry , protein kinase a , membrane , cortex (anatomy) , neuroscience , kinase , medicine , microbiology and biotechnology , endocrinology , epilepsy , biology , biochemistry
We demonstrated that only membrane‐associated protein kinase C (PKC) activity increased in the bilateral hippocampus (HIPP) up to 4 weeks and in the amyg‐dala/pyriform cortex (AM/PC) at 4 weeks after the last kindled seizure. The enhancement of the membrane‐associated PKC activity exceeds the increase in the protein concentration, which was observed in part. The overwhelming increase in the PKC activity should be of significance in the long‐term maintenance of the kindling phenomenon.