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Morphological Investigation of Iron‐Induced Epileptic Rats: With Special Reference to C‐fos Immunohistochemistry and Iron Staining
Author(s) -
Mizukawa Kiminao,
Kabuto Hideaki,
Mori Akitane
Publication year - 1991
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1991.tb02473.x
Subject(s) - immunohistochemistry , epilepsy , staining , pathology , chemistry , medicine , biology , neuroscience
We investigated the iron‐induced epileptic rats with special reference to c‐ fos immunohistochemistry and iron histochemistry in order to elucidate the pathogenesis of post‐traumatic epilepsy. The c‐ fos ‐immunopositive neurons were observed in a hippocampal formation, especially in the dentate gyrus and CA1 and CA2, in the vicinity of the iron injected cerebral cortex and amygdala only at 3 hours after the iron administration. Three days later after administration, several heavily positively iron staining cells and nerve fibers were observed around the injection site. In the cases of 3 weeks after administration, the large cavity and gliosis were characteristically observed.