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Mechanism of Electrographic Seizure Generation in the Rat Brain Slice in Low Magnesium Medium: Modulatory Effect of Interictal Bursting on Seizure Generation
Author(s) -
Kojima Hisashi,
Kowada Masayoshi,
Bragdon Andrew C.
Publication year - 1991
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1991.tb02472.x
Subject(s) - ictal , bursting , entorhinal cortex , subiculum , neuroscience , hippocampus , psychology , epilepsy , dentate gyrus
In order to understand the mechanisms underlying seizure generation, the present study investigated the functional and anatomical interaction between seizures and interictal bursts. Bathing rat brain slices of the hippocampus and entorhinal cortex in zero magnesium medium elicited electrographic seizures. In the later period, the electrographic seizures were eventually replaced by the interictal bursts. In this phase, lowering [K + ] 0 and raising [Ca 2+ ] 0 , restored the tonic seizures by suppressing the interictal bursts. A multiple knife cut experiment revealed that the seizures arose in the entorhinal cortex and the interictal bursts originated in CA3. A selective knife cut across the subiculum showed that the interictal bursts, propagating from CA3 to the entorhinal cortex, disrupted and suppressed the electrographic seizures in standard Mg–free medium.