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Methamphetamine‐Induced Dopamine Release in the Medial Frontal Cortex of Freely Moving Rats
Author(s) -
Kashihara Kenichi,
Hamamura Takashi,
Okumura Kazuya,
Otsuki Saburo
Publication year - 1991
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1991.tb01190.x
Subject(s) - dopamine , methamphetamine , frontal cortex , striatum , chemistry , neuroscience , microdialysis , extracellular , cortex (anatomy) , endocrinology , medicine , psychology , biochemistry
The effect of niethamphetamine (MAP) on the efflux of endogenous dopamine (DA) in the medial frontal cortex of freely moving rats was evaluated by a micro‐dialysis technique. The injection of MAP at 4 mg/kg, i.p., increased the extracellular levels of DA and decreased the levels of 3,4‐dihydroxyphenylacetic acid significantly. Although the changes were smaller than those observed in the striatum, the direction and time course were similar. MAP increases the efflux of DA in the medial frontal cortex.