Premium
The Effect of Intracerebroventricular Administration of Somatostatin on Prolactin and TSH Release in Rats
Author(s) -
Kaneda Hiroyuki,
Tanimoto Kenji,
Shintani Takeshi,
Kakigi Tatsuya,
Maeda Kiyoshi
Publication year - 1991
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1991.tb00531.x
Subject(s) - medicine , sulpiride , endocrinology , prolactin , somatostatin , antagonist , hormone , chemistry , receptor antagonist , receptor
We investigated the effect of intracerebroventrciular (icv) administration of somatostatin (SRIF) on prolactin (PRL) and thyroid‐stimulating hormone (TSH) release in freely moving rats chronically cannulated with en atrial catheter. The plasma PRL levels were significantly elevated following the icv administration of 0.5 ug SRIF. No further increase in PRL following the icv administration of SRIF were found in the rats in the course of repeated intravenous of injection of 5.0 mg/kg sulpiride, a specific D2 receptor antagonist. On the other hand, the injection of 5.0 /ig SRIF resulted in no significant change in the plasma TSH levels. These results suggest that the effect of SRIF on PRL release was exerted through brain D2 receptors.