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Demyelinating Peripheral Neuropathy in Devic Disease
Author(s) -
Aimoto Yasuharu,
Ito Kazunori,
Moriwaka Fumio,
Tashiro Kunio,
Abe Kazuhiro
Publication year - 1991
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1991.tb00525.x
Subject(s) - remyelination , medicine , neuromyelitis optica , demyelinating disease , peripheral , peripheral nervous system , spinal cord , multiple sclerosis , peripheral neuropathy , pathology , sural nerve , central nervous system , disease , myelin , immunology , psychiatry , diabetes mellitus , endocrinology
This is a report of a 20‐year‐old man with typical features of Devic disease (neuromyelitis optica) associated with demyelinating peripheral neuropathy. A sural nerve biopsy showed markedly decreased myelinated fibers of a large diameter. Teased fiber preparations showed segmental remyelination in 50% of examined fibers, as well as a few demyelination. Demyelination of bilateral optic nerves, spinal cord, and peripheral nerves at the same time suggests a possibility of common pathogenetic mechanisms in both the central and peripheral nervous systems.