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Linkage Analysis of Affective Disorder Using DNA Markers on Chromosomes 11 and X
Author(s) -
Nanko Shinichiro,
Kobayashi Masaru,
Gamou Shinobu,
Kudoh Jun,
Shimizu Nobuyoshi,
Takazawa Noboru,
Kazamatsuri Hajime,
Furusho Toshiyuki
Publication year - 1991
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1991.tb00505.x
Subject(s) - genetics , pedigree chart , genetic linkage , linkage (software) , chromosome , biology , gene , x chromosome , genetic marker
We have investigated two pedigrees in an attempt to detect the putative linkages between affective disorder and c‐Ha‐ ras ‐1 oncogene and the insulin gene on chromosome 11, or hypoxanthhte phosphoribosyltransferase (HPRT) on X chromosome. The linkage between affective disorders and the markers on chromosomes 11 and X was ruled out with the assumption of no recombination.