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The Stabilizing Effect of Bestatin on the Resting Membrane Potentials of X‐Linked Muscular Dystrophy Mice
Author(s) -
Kishi Masahiko,
Kurihara Teruyuki,
Hidaka Takanobu,
Kinoshita Masao
Publication year - 1990
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1990.tb01635.x
Subject(s) - muscular dystrophy , chemistry , neuroscience , medicine , biology
The resting membrane potentials of X‐linked muscular dystrophy (mdx) mice are about 10 mV lower than those of control (C 57 BL/10Sc) mice. Also repetitive action potentials which resemble insertion myotonia are frequently recorded intracellularly from the mdx mice of various ages. When the mdx mice are treated with bestatin intraperito‐neally for 7 days, the RMPs improvement almost attained its normal levels. Repetitive action potential bursts (electrical myotonia) recorded at the time of microelectrode insertion had decreased or abolished after bestatin therapy. Another set of in vitro experiments to see direct action of bestatin to the hemidiaphragm preparations of the mdx mice reveal improvement in RMP's and a reduction in electrical myotonia within a 30‐minute exposure to Tyrode's solution with bestatin. Bestatin has a favorable direct effect on the muscle fiber membrane to stabilize RMP's and suppress muscle membrane irritability.