Premium
Pharmacological Studies on Lithium: Its Effect on Serotonergic Function
Author(s) -
Yamawaki Shigeto
Publication year - 1990
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1990.tb00449.x
Subject(s) - serotonergic , autoreceptor , neuroscience , inhibitory postsynaptic potential , mechanism of action , chemistry , lithium (medication) , 5 ht receptor , serotonin , receptor , postsynaptic potential , pharmacology , endocrinology , medicine , psychology , biology , in vitro , biochemistry
Summary The summary of the above results is demonstrated in Fig. 1. Li enhanced 5‐HT synthesis and 5‐HT release via its inhibitory effect on presynaptic 5‐HT autoreceptors. The increased 5‐HT level in synaptic cleft down‐regulated 5‐HT 1A and 5‐HT., receptors. The 5‐HT 1A ‐me‐diated AC activity and behaviors were enhanced, but the 5‐HT 2 ‐mediated PI turnover and behaviors were suppressed. These effects of Li on 5‐HT neurones might be involved in the mechanism of action of affective disorders.