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Biological Study of Alcohol Dependence Syndrome with Reference to Ethnic Difference: Report of a WHO Collaborative Study
Author(s) -
Yamashita Itaru,
Ohmori Tetsuro,
Koyama Tsukasa,
Mori Hideki,
Boyadjive Sergey,
Kielholz Paul,
Gastpar Markus,
Moussaoui Dris,
Bouzekraoui M.,
Sethi Brij B.,
Reyes Baltazar V.,
Vartanian Marat E.,
Fuente Juan R.,
German G. Allen,
Bohacek Nenad,
Sartorius Norman,
Morozov Peter,
Prilipko Leonid L.
Publication year - 1990
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1990.tb00444.x
Subject(s) - aldehyde dehydrogenase , acetaldehyde , ethnic group , alcohol dehydrogenase , alcohol , medicine , ethanol , chemistry , biochemistry , sociology , anthropology , gene
Summary: Inherited deficiency of acetaldehyde dehydrogenase type I (ALDH‐I) was found in 43% (50/117) of normals, 33% (27/82) of schizophrenics, but only 4% (5/113) of alcoholics among Japanese. The ALDH‐I deficiency was never found, however, in 146 mostly schizophrenic subjects from Europe (Basel, Moscow, Zagreb), Australia (Nedlands), India (Lucknow), Morocco (Casablanca) and Mexico (Mexico City). It was demonstrated that ALDH‐I deficiency produces the flushing syndrome which inhibits the development of drinking habit and alcohol dependence syndrome.