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Neuroendocrinological Effects of L‐Threo‐3, 4‐Dihydroxyphenylserine (DOPS), a Putative Norepinephrine Precursor, on Healthy Volunteers
Author(s) -
Semba Jun'ichi,
Nankai Masahiro,
Okubo Yoshiro,
Kato Masaaki,
Matsuura Masato,
Takahashi Ryo
Publication year - 1990
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1990.tb00443.x
Subject(s) - endocrinology , medicine , crossover study , dosing , prolactin , hormone , norepinephrine , placebo , chemistry , dopamine , pharmacology , alternative medicine , pathology
The effect of L‐threo‐3, 4‐dihydroxyphenylserine (DOPS) on plasma Cortisol, prolactin, thyrotropin‐stimulating hormone (TSH) and growth hormone concentrations was studied in nine healthy male volunteers. The drug was administered orally (300 mg or 600 mg DOPS) using a multiple crossover placebo‐controlled study design. Plasma hormone concentrations were measured at 30 minute intervals for 3 hours after dosing. Plasma DOPS peak concentrations were observed between 2 and 3 hours after dosing. DOPS, however, had no effect on plasma hormone concentrations and this may be attributed to the known low brain permeability of DOPS in healthy subjects.