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Pathological Observations in HTLV‐I Associated Myelopathy
Author(s) -
Kobayashi Itsuro,
Ota Kohei,
Yamamoto Kenji,
Murakami Hirohiko,
Maruyama Shoichi,
Kasajima Takeshi,
Masuda Akihiro
Publication year - 1989
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1989.tb03105.x
Subject(s) - gliosis , myelopathy , pathology , cerebrospinal fluid , autopsy , pathological , parenchyma , medicine , spinal cord , psychiatry
The following are the clinical and autopsy findings in a 63‐year‐old woman with myelopathy associated with the human T‐cell lymphotropic virus Type I (HTLV‐I). HTLV‐I antibody was positive in both the serum and cerebrospinal fluid (CSF). In the lower thoracic region, demyelination and the loss of axons were accompanied by a proliferation of astrocytes, and gliosis was found in the lateral columns. Perivascular and parenchymal infiltrations of macrophages, lymphocytes, and plasma cells were also observed, but neither viral inclusion bodies nor atypical lymphocytes were found.