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Fatty Acid Analysis of Galactolipids and Ganglioside in the Brains of Four Cases of Nasu‐Hakola Disease
Author(s) -
Yokoi Susumu,
Suzuki Kyoko,
Amano Naoji,
Yagishita Saburo
Publication year - 1989
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1989.tb03104.x
Subject(s) - ganglioside , galactolipids , palmitic acid , fatty acid , chemistry , biochemistry , white matter , composition (language) , cerebral cortex , cortex (anatomy) , polyunsaturated fatty acid , medicine , biology , endocrinology , gene , philosophy , chloroplast , radiology , neuroscience , magnetic resonance imaging , linguistics
A study was conducted on the fatty acid composition of cerebroside, sulfatide and ganglioside in the brains of 4 cases of Nasu‐Hakola disease. The percentage of short carbon chain (C.16‐C.18) nonhydroxy fatty acids of sulfatide in the cortex was much higher than that of the control and long‐chain (C.24‐) fatty acids showed a lower percentage. Sulfatide in the white matter was of the same tendency. The percentage of C.16:0 palmitic acid of ganglioside in the cortex was much larger than that of the control. Referring to the fatty acid composition of lipids in the literature, abnormalities of the fatty acid concentration, namely a high percentage of short‐chain fatty acids of sulfatide and ganglioside in the cerebral cortex of the present cases, were confirmed.