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MRI Lesion and Epileptogenic Focus in Temporal Lobe Epilepsy
Author(s) -
Matsuda Kazumi,
Yagi Kazuichi,
Mihara Tadahiro,
Tottori Takayasu,
Watanabe Yutaka,
Seino Masakazu
Publication year - 1989
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1989.tb02933.x
Subject(s) - temporal lobe , hippocampal sclerosis , lesion , ictal , hippocampus , epilepsy , abnormality , medicine , hippocampal formation , magnetic resonance imaging , atrophy , psychology , neuroscience , radiology , pathology , psychiatry
The spatial relationship between a circumscribed lesion in the temporal lobe detected by MRI and an epibptogenic focus identified by ictal depth EEG along with a correlation, of the MRI lesion with neuropath logical findings were investigated in patients with medically intractable temporal lobe epilepsy but without any focal lesion on CT. Four parameters (an areal ratio of the temporal lobe against the hemisphere, area and calculated T1, T2 values of the hippocampus) were used to determine the abnormal MRI side. An agreement was reached in 67–72%, of 18 patients between the abnormal values of the hippocampus area and of calculated T1, T2 and the side of the epileptogenic focus. In 14 of 17 patients, typical hippocampus sclerosis was demonstrated in respected tissue in accordance with the MRI lesions (atrophy and/or prolonged T2 of hippocampus). These results imply: 1) MRI abnormality thus defined may, if not all, indicate the side of the epileptogenic focus, and 2) also the presence of hippocampal sclerosis. It was emphasized that the MRI lesion would be a usable instrument to explore the causal relationship of hippocampus sclerosis to a generation of epileptogenic lesions as well as for presurgical evaluation.