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A Treatment Trial of Delayed Sleep Phase Syndrome with Triazolam
Author(s) -
Ozaki Norio,
Iwata Tokihisa,
Itoh Akinori,
Ohta Tatsuro,
Okada Tamotsu,
Kasahara Yomishi
Publication year - 1989
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1989.tb02550.x
Subject(s) - triazolam , chronotherapy (sleep phase) , circadian rhythm , anesthesia , psychology , sleep (system call) , medicine , neuroscience , benzodiazepine , computer science , operating system , receptor
Triazolam causes a phase‐shift of the circadian rhythm of locomotor activity in golden hamsters. We attempted to treat two patients with delayed sleep phase syndrome (DSPS) with triazolam. In one male patient we administered triazolam when the sleep phase began to delay afkr chronotherapy. Triazolam combined with chronotherapy enabled him to normalize and stabilize his sleep‐wake cycle. But in the other female patient despite normalization of her sleep‐wake cycle, she became depressive and did not Continue taking the drug. In some cases triazalam is useful for the treatment of DSPS, but in others, triazolam induces a depressive state.