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Alterations of Accumbens Neuronal Activity in Freely Moving Rats Following Methamphetamine
Author(s) -
Fukuzako Hiroshi,
Nagatomo Itsugi,
Nomaguchi Mitsuo,
Takenouchi Kaoru,
Matsumoto Kei
Publication year - 1988
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1988.tb01984.x
Subject(s) - nucleus accumbens , methamphetamine , stereotypy , locomotor activity , premovement neuronal activity , neuroscience , pharmacology , psychology , chemistry , anesthesia , medicine , central nervous system , dopamine , amphetamine
Multiple unit activity in the nucleus accumbens, locomotor activity, and stereotyped behavior were simultaneously recorded in freely moving rats. An intra‐peritoneal injection of 1.5 mg/kg methamphetamine produced an increase in the firing rate while a decrease in the discharge rate occurred following an administration of 4.5 mg/kg methamphetamine. In addition, the unit activity was positively correlated with the locomotor activity and negatively correlated with the stereotypy score. These results suggest that accumbens neuronal activation during locomotor hyperactivity may partly depend on the feedback from locomotion.