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Rational Treatment of Refractory Epilepsy in Childhood
Author(s) -
Ohtsuka Yoko,
Ogino Tatsuya,
Amano Rumi,
Yamatogi Yasuko,
Oka Eiji,
Ohtahara Shunsuke
Publication year - 1988
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1988.tb01335.x
Subject(s) - epilepsy , exacerbation , polypharmacy , refractory (planetary science) , medicine , pediatrics , partial epilepsy , psychiatry , intensive care medicine , physics , astrobiology
Abstract: A multifaceted study on childhood refractory epilepsy disclosed an insufficient classification of epilepsies and epileptic seizures, and inappropriate polypharmacy as the most important factors preventing appropriate therapy. By means of an adjustment of AEDs based on the accurate classification of epilepsies and epileptic seizures, the number of AEDs could be reduced in 37.5% and monotherapy was successful in 13.8% of refractory cases. Most of the latter were those of partial epilepsy and generalized epilepsy with the monoseizure type. The exacerbation of seizures due to AEDs was also mentioned as one of the important side effects of AEDs.