Premium
Histopathological Changes Induced by Disturbance of Microcirculation in the Rat Brain
Author(s) -
Watanabe Kenjiro,
Miyakawa Taihei,
Katsuragi Shoichi,
Shimoji Akitomo,
Kuramoto Ryoko
Publication year - 1988
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1988.tb01174.x
Subject(s) - neuropil , microcirculation , disturbance (geology) , pathology , atrophy , degeneration (medical) , medicine , cortex (anatomy) , anatomy , biology , neuroscience , central nervous system , paleontology
Microcirculatory disturbance was induced in 8 rats after injecting micro‐sphere latex (5 micron in diameter) from the right carotid artery. Ultrastructural observations revealed that initial changes occurred in the vascular feet of astroglial cells the subsequent swelling of postsynapses. Succeedlngly presynapses nerve cells also became atrophic but this was considered to be caused by astrocytic degeneration. From these findings, it is speculated that the neuronai atrophy was secondary to the changes in the neuropil around the capillary caused by disturbance of the nutritional supply from the blood induced by micmcirculatory disturbance. The above described findings seemed to have some similarity to those of nonspecific degeneration of the cortex observed in the brain, such as Alzheimer's disease.