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F Response Abnormality in Parkinson's Disease
Author(s) -
Naito Yutaka,
Komatsu Yoshinari,
Kanazawa Ichiro,
Nakanishi Takao
Publication year - 1988
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1988.tb01170.x
Subject(s) - abnormality , parkinson's disease , dorsum , degenerative disease , neuroscience , motor neuron , disease , central nervous system disease , medicine , psychology , anatomy , spinal cord , psychiatry
The F response was recorded from the 1st dorsal interosseous muscle (1st DI) two antagonistic muscles, the flexor digitorurn brevis (FDB) the extensor digitorum brevis (EDB), in 16 patients with Parkinson's disease 22 age‐matched normal controls. In Parkinson's disease, the F responses from the 1st DI the FDB occurred more frequently with a longer duration a greater number of phases in comparison with the normal controls. In addition, the coefficient of variation of onset latency was significantly smaller in Parkinson's disease. On the other hand, the F response recorded from the EDB showed the same tendency as that from the FDB, but not to a significant extent. These findings suggest that the excitability of the spinal motor neurons is enhanced in rigid parkinsoninn patients. It thus seems reasonable to assume that the main underlying cause of rigidity is an excessive supraspinal drive to the spinal motor neurons, including an increase in motoneuron excitability.