Premium
Lp(a) Lipoprotein in Cerebrovascular Disease and Dementia
Author(s) -
Urakami Katsuya,
Mura Tetsuo,
Takahashi Kazuro
Publication year - 1987
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1987.tb00433.x
Subject(s) - dementia , lipoprotein(a) , cardiology , medicine , cerebral infarction , risk factor , occlusion , vascular dementia , cerebral atherosclerosis , intracerebral hemorrhage , lipoprotein , coronary artery disease , vascular disease , myocardial infarction , disease , ischemia , cholesterol , subarachnoid hemorrhage
Abstract: Lp(a) lipoprotein has been considered an independent risk factor in the development of coronary heart disease (CHD). We examined the role of Lp(a) in patients with cerebrovascular disease (CVD) and those with dementia. The Lp(a) concentration in patients with CHD, those with cerebral infarction due to a large artery occlusion and those with vascular dementia (VD) was significantly higher than that of age‐matched control subjects. However, the Lp(a) concentration was not high in cerebral infarction due to a small artery occlusion, intracerebral hemorrhage and dementia of the Alzheimer type (DAT). The present results suggest that Lp(a) should cause VD as well as CVD, and that Lp(a) should be one of the indicators that distinguish VD from DAT.