Premium
Cytosol Estradiol Receptor Content in the Adult Rat Brain after Neonatal Treatment with Estradiol Benzoate or Testosterone Propionate
Author(s) -
Takeshita Hisayoshi,
Shimizu Kyutaro,
Hazama Hidebumi
Publication year - 1987
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1987.tb00432.x
Subject(s) - medicine , endocrinology , hypothalamus , testosterone propionate , estradiol benzoate , amygdala , receptor , testosterone (patch) , estrogen , estrogen receptor , chemistry , cytosol , pituitary gland , androgen , hormone , biology , biochemistry , ovariectomized rat , cancer , breast cancer , enzyme
The effects of neonatal treatment with estrogen or androgen on the development of cytosol estradiol (E 2 ) receptors were examined in the rat pituitary, hypothalamus and amygdala. The treatment with estradiol benzoate (EB, 100 μg) significantly reduced the E 2 receptor content in all of these regions in both sexes. But the treatment with testosterone propionate (TP, 1 mg) to the female rats significantly decreased the E 2 receptor content in the pituitary and hypothalamus but not in the amygdala. The TP treatment to the male rats decreased the E 2 receptor content in the hypothalamus and amygdala but not in the pituitary. The decreased cytosol E 2 receptors in the hypothalamus and amygdala seem to be implicated in preventing the normal sexual development.