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Bioavailability of a Film‐Coated Tablet of Valproate in Nonfasting Volunteers
Author(s) -
Ishikawa Tatsuya,
Horie Masayo,
Furuyama Miwako,
Ohuchi Masanobu,
Awaya Atsuko,
Sobajima Hisanori,
Suchi Mariko,
Yamaguchi Atsuko,
Okajima Kazuki,
Wanibe Masahiko
Publication year - 1987
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1987.tb00427.x
Subject(s) - cmax , bioavailability , fluorescence polarization immunoassay , absorption (acoustics) , pharmacokinetics , venous blood , dosage form , medicine , pharmacology , chemistry , chromatography , materials science , composite material
The bioavailability of a film‐coated tablet of valproate (VPA) in nonfasting volunteers was studied. Ten healthy adults received a single 200 mg (mean 3.55 mg/kg) film‐coated tablet, 15 minutes after breakfast. Venous blood was then taken at regular intervals of up to 4 or 7 hours after the dosage, and the serum VPA concentrations were determined by means of a fluorescence polarization immunoassay. VPA was slowly absorbed with the peak concentrations occurring 1.5 to 4 hours after the administration. The mean concentration (Cmax) and extent of absorption (area under the concentration‐time curve) between 1 and 4 hours were 22.2 μ/ml and 59.3 μtg‐h/ml, respectively. It was concluded that Cmax with a film‐coated tablet of VPA can be detected if blood is taken at around 3 hours after the dosage under nonfasting conditions.