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Acute Effect of TRH, Fhmarizine, Lithium and Zotepine on Amygdaloid Kindled Seizures Induced with Low‐Frequency Stimulation
Author(s) -
Minabe Yoshio,
Tanii Yasuyuki,
Tsunoda Masahiko,
Kurachi Masayoshi
Publication year - 1987
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1987.tb00426.x
Subject(s) - kindling , flunarizine , epilepsy , lithium (medication) , medicine , stimulation , antipsychotic , seizure threshold , pharmacology , anesthesia , psychology , anticonvulsant , psychiatry , schizophrenia (object oriented programming) , calcium
We assessed the acute effects of various drugs on amygdaloid kindled seizures induced with low‐frequency stimulations. We used the number of stimulating pulses required for the induction of epileptic afterdischarge (pulse‐number threshold; PNT) as an indicator of the seizure generating threshold and the duration of induced seizures (AD duration; ADD) as an indicator of the seizures. TRH increased the PNT without affecting the ADD at a high dose (1.2 mg/kg). Flunarizine decreased the PNT and ADD simultaneously at a high dose (50 mg/kg). Lithium increased the PNT without affecting the ADD at two doses (100 mg/kg, 200 mg/kg). Zotepine decreased the PNT without affecting the ADD at two doses (8 mg/kg, 16 mg/kg). We propose that the technique of low‐frequency kindling is a useful experimental model in assessing the effects of antipsychotic or antiepileptic drugs on the excitability of the limbic regions.