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Effects of Medroxyprogesterone Acetate on Sleep of Healthy Young Male Adults
Author(s) -
Kotorii Tatayu,
aka Kensaku,
Nakazawa Yoichi,
Matsunaga Hiroki,
Mieno Kenji,
Hatase Tetsuro,
Kodama Hidetsugu,
Nishida Takahiro
Publication year - 1987
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1987.tb00410.x
Subject(s) - medroxyprogesterone acetate , sleep (system call) , sleep stages , medicine , arousal , medroxyprogesterone , psychology , anesthesia , endocrinology , polysomnography , estrogen , apnea , neuroscience , computer science , operating system
The effects of a single 100 mg dose of medroxyprogesterone acetate (MPA) on human sleep were investigated using healthy young male adults. After a baseline night recording, two consecutive MFA nights and the following two withdrawal nights were recorded. The total sleep time was reduced after the 2nd MPA night and the decrease was significant on the 1st withdrawal night. The time of intrasleep awakening increased after the 2nd MPA night. Stage 1 sleep increased significantly on the 2nd MPA and 1st withdrawal nights. Stage 4 sleep decreased and the sleep latency gradually increased after the MPAadministration. REM sleep reduced slightly on the 1st withdrawal night. These results indicate that MPA has a mild arousal action on human sleep and that the action may be pronounced a few days after administration of MPA.