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Serum Levels of Maprotiline and Its Adverse Effects on Depressed Patients
Author(s) -
Kurata Kouichi,
Kido Hideki,
Hasegawa Mitsuru,
Inoue Masao,
Yamaguchi Nariyoshi
Publication year - 1987
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1987.tb00408.x
Subject(s) - maprotiline , adverse effect , pharmacology , medicine , depression (economics) , psychiatry , antidepressant , anxiety , macroeconomics , economics
The relationships between the side effects of maprotiline (MPT) andthe serum concentration of MPT and desmethylmaprotiline (DMPT) were investigated with 27 blood samplings in 15 depressed inpatients. There were significant correlations between the side effects and serum levels of MPT and DMPT. Mild side effects frequently occurred at levels of more than 130 ng/ml of MPT and 70 ng/ml of DMPT. At more than 220 ng/ml of the MPT levels and 110 ng/ml of DMPT levels, severe side effects occurred. Nearly sigmoidalserum level/side effect response curves occurred with both compounds.