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Mood Alterations and Sleep
Author(s) -
Rimon Ranan,
Fujita Masahiko,
Takahata Naohiko
Publication year - 1986
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1986.tb03137.x
Subject(s) - clomipramine , psychology , dysthymic disorder , antidepressant , sleep deprivation , depression (economics) , sleep (system call) , psychiatry , major depressive disorder , mood , audiology , medicine , clinical psychology , cognition , anxiety , computer science , economics , macroeconomics , operating system
We have reviewed literatures about neurobiological aspect of mood disorders in the light of abnormalities of REM sleep. A shortened REM latency is a consistent finding in depressed patients and may be considered a biological marker for depression. Most depressed patients with shortened REM latency also show non‐suppression on dexamethasone‐suppression test (DST). The commonly used antidepressant drugs cause a significant reduction in REM sleep. Patients with abnormal DST show a better response to sleep deprivation than those with normal DST. Recent studies indicated that borderline patients, primary dysthymic patients and obsessive‐compulsive patients (OCD) have shortened REM latency. Farthermore, patients with OCD have a fairly good response to antidepressant clomipramine. Diagnostic and therapeutic strategies can conceivably be related on the examination of sleep patterns of psychiatric patients.