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Opiate‐Antagonist Reversal of Neurological Deficits –Experimental and Clinical Studies–
Author(s) -
Namba Shimpei,
Nishigaki Shinichi,
Fujiwara Noriaki,
Wani Takao,
Namba Yoichiro,
Masaoka Tetsuya
Publication year - 1986
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1986.tb01613.x
Subject(s) - (+) naloxone , antagonist , medicine , opiate , cerebral blood flow , anesthesia , etiology , facilitation , arousal , trunk , psychology , neuroscience , ecology , receptor , biology
The proximal left M 1 and the common trunk of A 2 were clipped in 12 adult dogs. Naloxone was injected after placing the clips onto 6 dogs. Neither the systemic blood pressure nor the local cerebral blood flow were influenced by naloxone. In another group of 6 dogs with chronic right hemiplegia, naloxone proved passably effective in improving the hemiplegia. Eight patients with neurological deficits of various etiologies were administered levallorphan. The improvement in motor performance and/or elevation of mental activity was observed more or less in all but 2 of the patients. It was consideredthat the effect of opiate antagonists is based partially on the facilitation of synaptictransmission exaggerated by the arousal response.