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High 1,25‐Dihydroxyvitamin D and Low 25‐Hydroxyvitamin D Concentrations in Plasma in Patients Receiving Antiepileptic Drugs
Author(s) -
Maeda Kiyoshi,
Ikeda Hirotoh
Publication year - 1986
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1986.tb01612.x
Subject(s) - antiepileptic drug , vitamin d and neurology , medicine , epilepsy , plasma concentration , pharmacology , psychiatry
Plasma 25‐hydroxyvitamin D (25‐OH D), 1,25‐dihydroxy vitamin D (1,25‐(OH) 2 D) and parathyroid hormone (PTH) concentrations were determined in 30 outpatients receiving various antiepileptic drugs (AED). None of the patients exhibited high plasma PTH levels. The plasma 1,25‐(OH) 2 D levels were normal or high, a'though in a third of the patients the 25‐OH D levels were reduced. There was a corre'ation between the 25‐OH D and serum calcium levels. These findings suggest that the low plasma concentrations of 25‐OH D, not 1,25‐(OH) 2 D, might play an important part in the occurrence of AED‐induced disturbances of bone metabolism.